Alzheimer’s Prevention for Women: What Protects the Brain Most? Ep. 480

In this episode, we explore practical, effective strategies for preventing Alzheimer’s and supporting brain health, especially for women facing hormonal shifts during perimenopause and menopause. We explain the crucial role of estrogen in brain energy metabolism and why its decline increases vulnerability to dementia. You’ll learn how hormone replacement therapy can be helpful but isn’t the only way to protect your mind. Discover why reducing inflammation by stabilizing blood sugar, eating whole foods rich in omega-3 fats and polyphenols, and nurturing gut health is foundational for cognitive vitality. Strength training focusing on large muscle groups like the glutes and thighs releases brain boosting myokines and helps combat muscle loss that many women experience with age. We also cover promising medical options like GLP-1 medications, low dose lithium, and brain supporting peptides as potential tools alongside lifestyle efforts. If you want practical advice for maintaining mental sharpness, improving mood, and reducing Alzheimer’s risk, this episode is full of valuable insights for all ages. Embrace multiple strategies hormone balance, diet, exercise, and gut care to keep your brain functioning at its best for years to come. Join Pearl and Serene on the Trim Healthy Podcast (a.k.a. “The Poddy”). Welcome to the spot where Pearl and Serene share their knowledge and their hearts (along with Danny’s antics) on topics ranging from physical and mental health to spiritual truth, and, yes… even a little comic relief. Put your seat belts on though…it can get a little bumpy! This particular show can be lacking in “proper podcast behavior.” But this is where growth happens… this is where NEW knowledge is celebrated… and fundamental knowledge is respected. Get ready for imperfectly polite conversations about health and wellness… the place where cutting edge science meets ancient wisdom. Get Pearl and Serene’s latest book – Purchase Trim Healthy Wisdom and join the women that are ready to “rock 40 and beyond.” Explore the Store: Click here to visit Pearl and Serene’s online store with over 100+ products, optimized for peak health. Join Our Membership! Go to to access special series, recipes, and other exclusive content. Get in the best shape of your life! Access their premium workout series, Tribe Healthy, go to Join KIAORA: Pearl and Serene have launched a Bioidentical Hormone Replacement Therapy tele-health company that is available in nearly every state in the USA! Go to to learn more. Learn more about your ad choices. Visit megaphone.fm/adchoices

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Alzheimer’s Prevention for Women: What Protects the Brain Most? Ep. 480 is an episode from Trim Healthy Podcast w/Serene and Pearl by cabana.

This episode is 47:34 long.

This episode was published on Apr 2, 2026.

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