RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health

Depression and anxiety are often treated as chemical imbalances in the brain—but what if the real problem starts in the gut? In this episode of Revolution Health Radio, we dive deep into the gut–brain connection and the growing body of research linking gut inflammation, microbiome imbalance, and mood disorders. You’ll learn how inflammatory cytokines contribute to depression, why butyrate is emerging as a powerful antidepressant compound, and how specific probiotic strains can improve mental health outcomes. Chris also shares practical, evidence-based strategies—including diet, supplementation, and functional testing—to address root causes and support lasting emotional well-being. The post RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health appeared first on Chris Kresser .

You can listen to RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health online on Radio and Podcast. Open the player on this page to stream the available audio.

RHR: The Gut-Brain Connection: How Your Microbiome Affects Your Mental Health is an episode from Revolution Health Radio by Chris Kresser.

This episode is 29:46 long.

This episode was published on Feb 24, 2026.

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