The Accident That Built the GPCR Field — Bob Lefkowitz
Jul 8, 2026 - 01:30:36
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Same binding affinity. Same target. One compound worked in vivo. The other did nothing. The answer was how long each molecule stayed on the CRF receptor — seven hours versus fifteen minutes — and no one had thought to me...
The Off-Rate Nobody Measured is an episode from Dr. GPCR Podcast by Dr. Yamina Berchiche. Same binding affinity. Same target. One compound worked in vivo. The other did nothing. The answer was how long each molecule stayed on the CRF recept...
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Published Jul 22, 2026, 02:13:57 long, audio available.
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