Building GPCR Assays That Reflect Real Biology
The biggest signal is not the same as the truest one. Jane Lamerdin and Gaurav Agrawal of Eurofins DiscoverX on what actually makes a GPCR a...
Radio and PodcastLive Radio & Podcasts
Science & Medicine
Dr. GPCR Podcast
We bring you closer to dedicated scientists who work tirelessly to help understand GPCR pathophysiology.
Episodes
20 of 231 episodes
He Left Stanford to Decode Adhesion GPCRs - Antony Boucard
Adhesion GPCRs are the largest receptors in the human genome — and until recently, no one was certain they coupled to G proteins at all. Bou...
The GPCR Nobody Has Learned to Drug Yet — Schulte
Frizzled receptors look like GPCRs — but the field is split on whether they actually are. Gunnar Schulte has spent 25 years building the cas...
The Off-Rate Nobody Measured
Same binding affinity. Same target. One compound worked in vivo. The other did nothing. The answer was how long each molecule stayed on the...
The Accident That Built the GPCR Field — Bob Lefkowitz
Lefkowitz was told in 1973 that hormone receptors were a figment of his imagination. The work that proved otherwise became the molecular fou...
The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin
Most GPCR antibody failures are silent. The signal looks clean, the band is there, the experiment moves forward - until someone runs a knock...
Three Adhesion GPCRs and No Rulebook - Beatriz Blanco
Most receptors come with a history. Remulate came with a name — and almost nothing else. Dr. Beatriz Redondo, group leader at the University...
Chimeric GPCRs: Why the Easy Designs Fail — Charlotte Crauwels
What if two nearly identical GPCRs make a worse chimera than two receptors from completely different classes? Charlotte Crauwels is building...
The Beta-2 Agonist That Doesn't Stop Working — Tore Bengtsson
Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsson built one that doesn't. A profess...
One Molecule, Two Opioid Receptors - Joseph Kim
Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something dif...
Can Simulations Predict GPCR Ligand Bias?
How does ligand binding at the extracellular pocket of a GPCR reshape signaling on the intracellular side? Biased agonism is often measured...
Why Mosquitoes Hunt You: The GPCR Behind the Bite - Laura Duvall
Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut...
GPCR Location and Lipid Raft Signaling
Key Takeaways How does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional...
Choosing the Right GPCR Assays for Translational Drug Discovery 180
Episode Summary Potent in vitro hits often fail in vivo—Martin Marro details how robust assay choice and pathway deconvolution can revive GP...
How Academia–Industry Collaboration Is Scaling GLP-1 Receptor Tools | Dr. GPCR Podcast #179
GPCR tools don’t move the field forward unless researchers can actually use them. This episode breaks down how collaboration turns probes in...
Imaging GPCRs in Action: Chemical Probes for Next-Level Discovery | Dr. Johannes Broichhagen #178
Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture. This is Episode 2...
Mapping GLP-1 & GIP Receptors in Metabolic Disease with Dr. David Hodson - Episode 177
Precise receptor mapping is reshaping how we understand incretin biology. David Hodson explains how GPCR-targeted chemical probes reveal whe...
Inside Monash: Organized Signaling, Real Impact
What makes Monash a model for modern pharmacology? Dr. Michelle Halls reveals how collaboration, mentorship, and receptor organization shape...
Model. Predict. Discover. with Dr. Jens Carlsson | Dr. GPCR Podcast #175
Predicting, not just explaining, can change how we design GPCR-targeted drugs. Jens Carlsson reveals how modeling bridges structure, functio...
From Rare Earth Probes to Internalization Assays: The pHSense Story with Dr. Eric Trinquet from Revvity | Dr. GPCR Podcast #174
🔬 What if you could track GPCR internalization—no wash, high-throughput, and in endogenous systems? Discover how Dr. Eric Trinquet and Revv...