
The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin
Most GPCR antibody failures are silent. The signal looks clean, the band is there, the experiment moves forward - until someone runs a knock...
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Most GPCR antibody failures are silent. The signal looks clean, the band is there, the experiment moves forward - until someone runs a knock...

Most receptors come with a history. Remulate came with a name — and almost nothing else. Dr. Beatriz Redondo, group leader at the University...

What if two nearly identical GPCRs make a worse chimera than two receptors from completely different classes? Charlotte Crauwels is building...

Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsson built one that doesn't. A profess...

Dr. Joseph Kim solved cryo-EM structures of mu and kappa opioid receptors bound to the same small molecule — and found it does something dif...

How does ligand binding at the extracellular pocket of a GPCR reshape signaling on the intracellular side? Biased agonism is often measured...

Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut...

Key Takeaways How does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional...

Episode Summary Potent in vitro hits often fail in vivo—Martin Marro details how robust assay choice and pathway deconvolution can revive GP...

GPCR tools don’t move the field forward unless researchers can actually use them. This episode breaks down how collaboration turns probes in...

Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture. This is Episode 2...

Precise receptor mapping is reshaping how we understand incretin biology. David Hodson explains how GPCR-targeted chemical probes reveal whe...

What makes Monash a model for modern pharmacology? Dr. Michelle Halls reveals how collaboration, mentorship, and receptor organization shape...

Predicting, not just explaining, can change how we design GPCR-targeted drugs. Jens Carlsson reveals how modeling bridges structure, functio...

🔬 What if you could track GPCR internalization—no wash, high-throughput, and in endogenous systems? Discover how Dr. Eric Trinquet and Revv...

What if a failed med school plan led to a biotech breakthrough? Ajay Yekkirala shares how GPCRs, AI, and scientific curiosity are reshaping...

When fentanyl slows your breath and xylazine traps it, the clock starts ticking. PhD candidate Catherine Demery takes us inside her fight to...

Watch the video version of this podcast episode. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-171-with-alessandro-nicoli ------------...

Watch the video version of this podcast episode. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-170-with-dr-alex-serafini -------------...

Watch the video version of this podcast episode. https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin ----------------...