Chimeric GPCRs: Why the Easy Designs Fail — Charlotte Crauwels

Dr. GPCR Podcast by Dr. Yamina Berchiche

May 13, 202600:47:40Science & Medicine

What if two nearly identical GPCRs make a worse chimera than two receptors from completely different classes? Charlotte Crauwels is building computational tools to find out why — and to predict which designs will work be...

Related Episodes

Continue listening to more episodes from Dr. GPCR Podcast.

Building GPCR Assays That Reflect Real Biology

Sep 9, 2026 - 00:56:21

The biggest signal is not the same as the truest one. Jane Lamerdin and Gaurav Agrawal of Eurofins Discov...

He Left Stanford to Decode Adhesion GPCRs - Antony Boucard

Aug 26, 2026 - 01:40:33

Adhesion GPCRs are the largest receptors in the human genome — and until recently, no one was certain the...

The GPCR Nobody Has Learned to Drug Yet — Schulte

Aug 12, 2026 - 01:08:53

Frizzled receptors look like GPCRs — but the field is split on whether they actually are. Gunnar Schulte...

The Off-Rate Nobody Measured

Jul 22, 2026 - 02:13:57

Same binding affinity. Same target. One compound worked in vivo. The other did nothing. The answer was ho...

The Accident That Built the GPCR Field — Bob Lefkowitz

Jul 8, 2026 - 01:30:36

Lefkowitz was told in 1973 that hormone receptors were a figment of his imagination. The work that proved...

The GPCR Antibody Nobody Could Validate - GeneTex - Alexander Ball & Chia-Yi Lin

Jun 17, 2026 - 00:41:04

Most GPCR antibody failures are silent. The signal looks clean, the band is there, the experiment moves f...

Three Adhesion GPCRs and No Rulebook - Beatriz Blanco

May 27, 2026 - 00:44:20

Most receptors come with a history. Remulate came with a name — and almost nothing else. Dr. Beatriz Redo...

The Beta-2 Agonist That Doesn't Stop Working — Tore Bengtsson

May 6, 2026 - 00:45:55

Every beta-2 agonist ever tested for muscle growth hits the same wall: desensitization. Dr. Tore Bengtsso...