The 5-Step Framework for AI Agents That Improve While You Sleep E2269

This Week In Startups is made possible by: Quo - https:// quo.com/TWiST LinkedIn Jobs - https:// LinkedIn.com/twist Iru - https:// iru.com/twist Plaud - https:// Plaud.ai/twist Today’s show: Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters. He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team: Start with one agent and onboard them like a new hire Stop Googling fixes; just ask your agent how to use it Put your agents on fixed schedules Add shared memory so you don’t have to repeat yourself Let agents run self-reviews and rewrite their own instructions. Get the walkthrough to put this entire plan into practice on today’s episode. PLUS fresh demos of the “Minecraft”-inspired virtual workspace MoltWorld and AgentMail, which is Gmail for your AI pals, and Jason explains the thinking behind his viral, controversy-stirring “don’t talk to journalists” tweet. Follow Shubham: “How I Built an Autonomous AI Agent Team That Runs 24/7” on X: Follow Mike: MoltWorld: Follow Haakam: AgentMail: Jason’s post about talking to journalists: NYT responds: Translated Japanese tweets: , Japanese people singing “Country Roads”: Trailer for “Nuremberg” (now on Netflix in the US): Timestamps: 0:00 Intro 1:24 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at and use code TWIST for 10% off! 3:05 We're Claw-pilled once again; it's an all AI Agent showcase 6:15 Google AI PM Shubham Saboo's Top 5 OpenClaw tips 10:14 Quo (formerly OpenPhone) gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at 13:26 Tip — Onboard your agent like a new hire 17:31 Tip — Talk to your agents constantly 19:02 Tip — Put your agents on a schedule 19:51 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at 23:41 Tip — Add cross-agent memory 29:33 Tip — Let your agents self-improve 29:51 Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at 34:03 Why Jason says founders should avoid journalists 38:24 How biased IS the New York Times? 47:02 DEMO: Co-founder Mike Nosov shows us MoltWorld 51:14 But what's the utility of this? 1:05:15 DEMO: Haakam Aujla presents AgentMail (YC S25) 1:09:59 How does AgentMail make money? 1:17:03 How Grok Translations are creating cross-cultural dialogue on X

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The 5-Step Framework for AI Agents That Improve While You Sleep E2269 is an episode from This Week in Startups by Jason Calacanis.

This episode is 01:27:14 long.

This episode was published on Mar 31, 2026.

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