Anthropic’s Mythos is a cyber-weapon, so you can’t have it E2273

Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction. Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council. Together, they’ll test how quickly and easily the model can thwart today’s most elite cybersecurity protocols, and try to develop fresh protocols to keep our most sensitive and critical software systems safe and intact. Once Mythos or a similarly powerful model hits the streets… it’s all over! Plus, we’re checking out the real-time SaaSpocalypse monitor Death By Clawd, and chatting with its creator, Gyani, about how it feels to have your startup one-shotted by Anthropic’s latest model. Guests Rob May: Neurometric: Neurometric SLM Marketplace: Death by Clawd: Nick O’Neill: This Week In Startups is made possible by: LinkedIn Jobs - LinkedIn.com/twist Grasshopper Bank - Grasshopper.bank/twist Render - Render.com/twist Plaud - Today’s show: Timestamps: 0:00 Anthropic's new, powerful 'Mythos' model 3:50 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at and use code TWIST for 10% off! 5:26 Neurometric's Rob May joins the show 10:04 Sam Altman's talent exodus 10:50 Render - Go to to apply for the Render Startup Program. You'll get anywhere from $500 to $100,000 in free credits. 11:50 Has Anthropic Passed OpenAI? 15:44 When will Claude release Mythos? Polymarket: 18:32 The AI race turns existential 19:16 Would Anthropic's model give the CIA the ability to hack a foreign government? 20:04 Grasshopper Bank - Time is money. Don't waste either. Go to and get an exclusive $500 cash bonus just for opening an account. 21:19 Should AI be nationalized? 29:43 Subsidizing secret AI development. 30:15 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at 31:29 How much of the military's $1.5T will go to AI cybersecurity? 35:17 Nick O'Neill's "not sponsored" call-in. 38:24 What is an SLM? 42:01 Tactical/Practical: How can you tune SLMs 45:43 How Neurometric can afford 100M free tokens per month for its users? 49:04 What is "harness engineering"? 50:58 Tactical/ Practical: Every Reddit rant is a startup idea 1:00:25 Why Meta is the most un-innovative AI company in the world. 1:03:43 Gyani of Deathbclawd joins the show — Is your company COOKED?

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Anthropic’s Mythos is a cyber-weapon, so you can’t have it E2273 is an episode from This Week in Startups by Jason Calacanis.

This episode is 01:16:48 long.

This episode was published on Apr 9, 2026.

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