3 AI Agents That Actually Replaced Human Jobs E2272

Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it’s going to cost now, and whether this is truly the end of the subsidized AI era. And they all brought demos! We’re checking out ClawChief from Ryan Carson, Alex Finn’s agent Henry, and Yazin Alirhayim’s Sidecast protocol, inspired by a special request from JCal! Hosts Jason Calacanis: Lon Harris: Guests Ryan Carson: Clawchief: Alex Finn: Creator Buddy: Yazin Alirhayim: OpenOats / Sidecast: Further Reading The Checklist Manifesto by Atul Gawande: Marc Andreessen on AI job loss: OpenAI acquires TBPN: This Week In Startups is made possible by: Gusto - Vanta - Shopify - Plaud - Today’s show: Timestamps: 0:00 Welcome back to TWiST 0:32 Jason's thinks Andor is as good as Empire Strikes Back… 2:30 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at and use code TWIST for 10% off! 3:26 Check out the checklist manifesto! 6:36 Our guests Ryan Carson, Alex Finn, and Yazin Alirhayim, and join the show 10:28 Gusto - Check out the online payroll and benefits experts with software built specifically for small businesses and startups. Try Gusto today and get three months FREE at 10:46 People are automating their coworkers and getting them fired… 18:32 Anthropic Bans OpenClaw 20:06 Vanta - Get $1000 off your SOC 2 at 24:06 How "caveman talk" makes AI works better 27:31 Alex thinks $2000/ month subscription plans are inevitable for AI. 29:31 Why is nobody using the leaked Anthropic Model? 30:30 Shopify: Turn those What If's into sales with the ecommerce platform powering millions of businesses. Sign up for your $1-per-month trial today at 32:37 Open models have been 6 months behind for the past few years 35:53 Why did OpenAI acquire TBPN? 42:01 Tactical/ Practical: The product itself is the most important thing 44:31 Demo or Die! Yazin is back to show off OpenOats 55:05 Ryan's "Claw Chief" 1:02:14 Alex's big announcement, "Henry intelligent machines" 1:12:33 Alex Finn DESTROYS Higgsfield's marketing strategy 1:15:35 Throwback to "Pay Per Post"

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3 AI Agents That Actually Replaced Human Jobs E2272 is an episode from This Week in Startups by Jason Calacanis.

This episode is 01:19:09 long.

This episode was published on Apr 7, 2026.

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