Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health

In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue. We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You’ll discover why bagfuls of supplements aren’t enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at To become a Certified Functional Medicine practitioner, visit Try our 7-day free trial, no credit card required. 00:00 Factors affecting mitochondrial function 03:55 Optimizing patient bioenergetics basics 09:27 Mitochondria and cell evolution 12:33 Focus on acquired mitochondrial dysfunctions 14:23 Mitochondrial ATP production process 20:22 Ketogenic diet and energy pathways 21:15 Ketogenic diet for chronic fatigue 27:02 Exploring functional medicine resources Support this show . Hosted on Acast. See acast.com/privacy for more information.

You can listen to Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health online on Radio and Podcast. Open the player on this page to stream the available audio.

Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health is an episode from Solving the Puzzle with Dr. Datis Kharrazian by Datis Kharrazian.

This episode is 28:13 long.

This episode was published on May 20, 2026.

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