Episode 67: Hallmarks of Aging and Disease

In this episode, Dr. Datis Kharrazian explores longevity medicine and the hallmarks of aging and disease. How do early signs of loss of resilience—like cognitive decline or changes in physical appearance—offer clues about our biological age? What can cutting-edge studies, such as the Dunedin Longitudinal Study, teach us about predicting poor aging trajectories and preventing chronic diseases like cardiovascular issues and cancer, before they silently take hold? Dr. Kharrazian uncovers the mechanisms underlying tissue degeneration, explores why resilience is central to healthy aging, and explains how functional medicine clinicians can use biomarkers and in-depth assessments to help shift morbidity later in life. Whether you’re a healthcare practitioner, a nutrition enthusiast, or facing chronic health challenges, this episode bridges the gap between complex science and actionable steps you can implement right now. Learn functional longevity strategies from Dr. Datis Kharrazian. Discover how to use personalized nutrition, diet, and lifestyle approaches to optimize healthspan. Enroll in the Longevity Mastery Program at: For patient-oriented functional medicine courses, visit For practitioner functional medicine certification courses, visit For Certified Functional Nutrition education for both practitioners and lay people, visit 00:00 "Longevity, Wellness, and Disease" 03:51 "Pace and Markers of Aging" 09:02 "Aging Mechanisms and Disease Links" 13:33 Aging, Resilience, and Clinical Outcomes 14:52 "Hallmarks of Aging Explained" 20:11 "Aging Tissues and Inflammation" 22:18 Mitochondria, Aging, and Vascular Health 25:59 Cancer Warning Signs 32:21 "Aging's Role in Cancer Progression" 33:13 "Functional Health Solutions Podcast" Support this show . Hosted on Acast. See acast.com/privacy for more information.

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Episode 67: Hallmarks of Aging and Disease is an episode from Solving the Puzzle with Dr. Datis Kharrazian by Datis Kharrazian.

This episode is 34:24 long.

This episode was published on Jan 6, 2026.

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