The OPTIMUM Trial: A Roadmap for Treatment-Resistant Depression in Late Life

Psychopharmacology and Psychiatry Updates by Psychopharmacology Institute

Jul 30, 202616:31Health

In this episode, we explore the OPTIMUM trial, a landmark study examining how to treat older adults with treatment-resistant depression when antidepressants fall short. When adding a medication outperforms switching enti...

Related Episodes

Continue listening to more episodes from Psychopharmacology and Psychiatry Updates.

EMERGENT-5: Cobenfy and Treatment Durability

Sep 18, 2026 - 12:55

In this episode, we sit down with Dr. Oliver Freudenreich to unpack EMERGENT-5, the year-long trial track...

Antipsychotics and Weight Gain

Sep 13, 2026 - 14:59

In this episode, we sit down with Dr. Oliver Freudenreich to unpack antipsychotic-induced weight gain — w...

EPA vs. DHA: Fish Oil and Treatment-Resistant Depression

Sep 8, 2026 - 12:41

In this episode, we explore whether EPA, a specific omega-3 fatty acid, can help patients with treatment-...

AUD Medications and Hepatic Safety

Sep 3, 2026 - 10:14

In this episode, we explore how liver status shapes medication choice for alcohol use disorder. Dr. Kevin...

GLP-1 Agonists in Serious Mental Illness: Current Evidence

Aug 29, 2026 - 15:27

In this episode, we explore whether GLP-1 agonists like semaglutide can tackle the metabolic toll of anti...

Gabapentin, Topiramate & Baclofen in AUD

Aug 24, 2026 - 17:22

In this episode, we explore three off-label but evidence-supported medications — gabapentin, topiramate,...

Deprescribing Benzodiazepines: When Tapering Might Do More Harm Than Good

Aug 19, 2026 - 17:01

In this episode, we explore the nuanced landscape of benzodiazepine tapering, guided by a major 2024 join...

Disulfiram Unpacked: Efficacy, Risks, and Liver Safety

Aug 14, 2026 - 16:11

In this episode, we explore disulfiram (Antabuse), one of the oldest FDA-approved treatments for alcohol...