S4:E2 - Making Sulfur Smell like Success!

Join us on the Pharm to Table podcast for a delightful chat with Ethan Wappes from our South San Francisco site, as we dive into the exciting world of thiophene synthesis! Ethan is a member of our Discovery Process Chemistry group and worked alongside medicinal chemists to devise a better synthetic route towards substituted thiophenes. Ethan shares insights from his recent Org. Lett. on a novel Rh-catalyzed [3+2] method that opens the door to highly substituted dihydrothiophenes, enhancing our medicinal chemistry toolkit. We explore how this strategy not only simplifies complex thiophene syntheses but also paves the way for new drug development possibilities! Read the papers we discussed today: Fully Substituted Thiophene Synthesis via (3 + 2) with Thiadiazoles - Org Lett 2024 Follow the Pharm to Table podcast on X - ⁠⁠⁠⁠@PharmtoTablePod ⁠⁠⁠⁠Visit our website at ⁠⁠⁠⁠

You can listen to S4:E2 - Making Sulfur Smell like Success! online on Radio and Podcast. Open the player on this page to stream the available audio.

S4:E2 - Making Sulfur Smell like Success! is an episode from Pharm to Table by LC Campeau, Dani Schultz.

This episode is 00:26:40 long.

This episode was published on Apr 21, 2025.

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