SE5:E4 - Part 1: Protecting Groups? We Need to Talk: Manufacturing MK-0616 with Enzyme Cascades
How do you design a manufacturing process for a molecule as complex as MK-0616 ? In Part 1 of this Pharm to Table series, Dani and LC join S...
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Pharm to Table
A podcast hosted by L.-C. Campeau and Dani Schultz that dives into the stories about the people behind the chemistry and science that happens at #MerckChemistry. Follow us on Twitter at @Pha...
Episodes
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SE5:E5 - Part 2: Protecting Groups? We Need to Talk: Manufacturing MK-0616 with Enzyme Cascades
Part 1 laid out the strategy. Now, it’s time to make the molecule. Four enzymes, one vessel, and plenty of competing amines. What could poss...
SE5:E3: A Process Chemist's Romance with Scaling a Macrocyclic Peptide
Last episode, we watched medicinal chemistry dream up enclitide (MK-0616) — this week we find out what happens when someone actually has to...
SE5:E2: The Macrocyclic Mullet
What happens when the textbook SAR playbook stops working? On this episode of Pharm to Table , Rob Garbaccio joins Dani and LC to share the...
SE5:E1 - A Journey of Synthetic Chemistry Innovations at Merck
To kick off Season 5, Dani and LC discuss a recent perspective published in the Journal of Organic Chemistry that highlights innovations in...
SE4:E8: From Discovery to Process, Part 2: Getting Ugi with it - scaling a 3CL protease inhibitor
In Part 2 of our Pharm to Table deep dive on MK‑7845, Dani and LC shift from invention to implementation, welcoming process chemists Nastara...
SE4:E7: From Discovery to Process, Part 1: Building a 3CL Protease Inhibitor Through Smart Fluorine Placement and Design Intuition
In this first installment of our two‑part Pharm to Table special on MK‑7845, Dani and LC sit down with medicinal chemist Valerie Shurtleff t...
SE4:E6 - Mechanism-Driven Innovation in Process Research: Yining Ji Chen’s Road as a Rising Star
Join us for a conversation with Yining Ji Chen, recipient of the 2025 ACS Rising Star Award, on how mechanistic insight powers innovation in...
SE4:E5 - Evolution of a Green Chemistry Trailblazer
In this episode, Dani and LC welcome Jeff Moore, recipient of the 2025 ACS Affordable Green Chemistry Award, to discuss his pioneering work...
SE4:E4 - MedChem Masters: Molecules, Mentors and Mindsets
In this episode, Dani and LC interview Dr. Shane Krska, recipient of the ACS Arthur C. Cope Award, and Dr. Petr Vachal, recipient of the ACS...
S4:E3 - London Calling ... Spirocycles
This month we sit down with Damien Valette, Olivia Boyd and David Petrone to chat about their latest paper in Organic Letters on the desymme...
S4:E2 - Making Sulfur Smell like Success!
Join us on the Pharm to Table podcast for a delightful chat with Ethan Wappes from our South San Francisco site, as we dive into the excitin...
S4:E1 Chemistry Unplugged: Listener Q&A and Future Insights
We're kicking off Season 4 (holy cow!) by having a lively discussion answering listener questions on everything from our favorite Boc deprot...
S3:E10 - Look what ADCs made us do
Antibody drug conjugates, or ADCs, are all the rage in the industry right now and chemists play an important role in their development. This...
S3:E9 - Surfing peptide production by going with the flow
Ready to go with the flow? Then this episode is for you! In this episode, we dive into the exciting world of Continuous-Flow Solid-Phase Pep...
S3:E8 - So you think you want to start a chemistry podcast?
Join Dani and LC as they peel back the layers on podcasting in chemistry. This insightful episode dives into their recently published Organi...
S3:E7 - Your Rx for a Pharma Job: Insider Secrets (Part 2)
Time for the main course! Our #MerckChemistry hiring experts are dishing out more savory tips to help you get hired in pharma. In this secon...
S3:E6 - Your Rx for a Pharma Job: Insider Secrets (Part 1)
Looking to kickstart your career in the pharmaceutical industry? This episode is a must-listen! We have special guests Jamie McCabe Dunn, Va...
S3:E5 - When Robots Work-It-Up!
Alexandra Sun and Harrison Rose join the pod to share their work on a vision-guided automated liquid-liquid extraction (LLE) platform. That'...
S3:E4 - "Asta La Vista, Baby" - The Aminator
Patrick Fier and Suhon Kim join the pod to share their lates collaboration on a new C-N cross-coupling protocol which leverages a novel mult...