S3:E3 - A chemist, a physicist and an enzyme walk into a bar...

Nadine Kuhl (process chemist) and Jacob Forstater (engineer and physicist) join the pod to share a pretty neat story that had its origins from a chemical catalog brochure advertising a new and green solvent called Cyrene. From that brochure blossomed a really amazing biocatalytic transamination to make a key chiral amine building block. In order to make this process more robust and tolerant of organic solvents, the team immobilized the transaminase enzyme and leveraged a Spinchem rotating bed reactor (we also had no idea what this was, but now we do) to make a robust process. We learned a lot on this episode, and we hope you do too! Read the papers we discussed today: Amination of a green solvent via immobilized biocatalysis for the synthesis of nemtabrutinib - ACS Catalysis Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene - Green Chemistry Follow the Pharm to Table podcast on Twitter - ⁠⁠⁠@PharmtoTablePod⁠⁠⁠ Visit our website at ⁠⁠⁠

You can listen to S3:E3 - A chemist, a physicist and an enzyme walk into a bar... online on Radio and Podcast. Open the player on this page to stream the available audio.

S3:E3 - A chemist, a physicist and an enzyme walk into a bar... is an episode from Pharm to Table by LC Campeau, Dani Schultz.

This episode is 00:34:48 long.

This episode was published on Feb 20, 2024.

Yes. Use the heart button on the episode page to add it to your favorite episodes list.

Yes. This page shows related episodes from Pharm to Table when more episodes are available from the podcast feed.