Why Centenarians Are Defying Science: Secrets to Living 100+

It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases. We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one... stay tuned. Check out the show notes at for all the relevant links and resources. ~DrKF Check out the show notes at for the full list of links and resources. GUEST DETAILS Nir Barzilai M.D. Director of the Einstein Institute for Aging Research Professor of Medicine and Genetics President of the Academy for Health & Lifespan Research Website: Email: nir.barzilai@einsteinmed.edu Dr. Nir Barzilai is a pioneer in aging science, known for his work on centenarians, the biology of aging, and the TAME trial. He is Director of the Institute for Aging Research at Albert Einstein College of Medicine and author of Age Later and has published over 330 papers. THANKS TO OUR SPONSORS DIAMOND DUTCH: Biotics Research: GOLD Vibrant Wellness: OneSkin: EXCLUSIVE OFFERS FROM OUR SPONSORS Find out why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA CONNECT with DrKF Want more? Join our newsletter here: Or take our pop quiz and test your BioAge! YouTube: Instagram: Facebook: DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: Younger You Practitioner Training Program: Younger You book: Better Broths and Healing Tonics book:

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Why Centenarians Are Defying Science: Secrets to Living 100+ is an episode from New Frontiers in Functional Medicine by Dr. Kara Fitzgerald - Functional Med & Longevity.

This episode is 01:22:19 long.

This episode was published on Aug 17, 2025.

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