The Tough Gut Playbook: Rebuilding Gut Resilience in IBS-Prone Patients

As more patients present with digestive sensitivity and increasingly restricted diets, restoring gut resilience has become a central clinical challenge. In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald speaks with Colleen Cutcliffe, PhD, CEO and co-founder of Pendulum Therapeutics, about emerging microbiome science and practical strategies for supporting microbial balance, dietary tolerance, and metabolic health. The discussion explores next-generation probiotic strains, fiber diversity, IBS patterns, and real-world approaches clinicians can use to help patients rebuild microbiome resilience and expand diet diversity in practice. Full show notes + references: GUEST DETAILS Colleen Cutcliffe, PhD, is CEO and Co-Founder of Pendulum Therapeutics, where she focuses on advancing microbiome science and metabolic health through next-generation probiotic research. She holds a PhD in Biochemistry and Molecular Biology from Johns Hopkins University and brings more than 25 years of experience across biotechnology, pharmaceuticals, and academic research. THANKS TO OUR SPONSOR Pendulum Therapeutics - Email: hello@pendulumlife.com EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Using next-generation probiotics like live Akkermansia, Pendulum is designed to go beyond gut health to support metabolism. Visit and use code KARA20 for 20% off your first membership order. CONNECT with DrKF Want more? Join our newsletter here: Or take our pop quiz and test your BioAge! YouTube: Instagram: Facebook: DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: Younger You Practitioner Training Program: Younger You book: Better Broths and Healing Tonics book:

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The Tough Gut Playbook: Rebuilding Gut Resilience in IBS-Prone Patients is an episode from New Frontiers in Functional Medicine by Dr. Kara Fitzgerald - Functional Med & Longevity.

This episode is 00:55:49 long.

This episode was published on Mar 24, 2026.

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