Muscle, Ageing, and the Hidden Cost of Weight Loss - with Prof. David Scott

Save 20% on all Nuzest Products WORLDWIDE with the code MIKKIPEDIA at , or Curranz Supplement: Use code MIKKIPEDIA to get 20% off your first order - go to or to order yours NZ listeners - save 10% off Calocurb by using the code Mikkipedia10 at This week on the podcast, Mikki speaks to David Scott, Professor of Clinical Epidemiology at Monash University and a leading expert in muscle health, ageing, and body composition. In this episode, the conversation centres on one of the most important areas of metabolic health: skeletal muscle. Prof Scott unpacks why muscle mass and function are critical for healthy ageing, and how this becomes increasingly complex in the context of obesity, weight loss, and modern treatment approaches. Mikki and Prof Scott explore the tension between improving metabolic health and preserving muscle, including what happens to lean mass during weight loss and why muscle quality matters as much as quantity. They also discuss practical strategies around resistance training and protein, and how these may need to shift across the lifespan. The discussion then turns to GLP-1 receptor agonists and their growing role in obesity management, examining what we know so far about their impact on muscle mass, strength, and long-term health outcomes. This is a broad, evidence-based conversation that brings muscle back to the centre of the metabolic health discussion, with clear takeaways for both clinicians and individuals. David Scott is a Professor of Clinical Epidemiology at Monash University, with a research focus on musculoskeletal health, ageing, and body composition. His work centres on understanding and preventing age-related declines in muscle mass and function, including sarcopenia and frailty. He has a particular interest in how lifestyle factors such as nutrition, physical activity, and body weight influence muscle quality, strength, and overall functional capacity across the lifespan. Professor Scott’s research also explores the intersection of obesity and muscle health, including the concept of sarcopenic obesity, as well as the effects of weight loss and emerging therapies on lean mass and physical function. His work contributes to the development of evidence-based strategies to support healthy ageing, maintain independence, and reduce the burden of chronic disease. Professor Dave Scott: Contact Mikki:

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Muscle, Ageing, and the Hidden Cost of Weight Loss - with Prof. David Scott is an episode from Mikkipedia by Mikki Williden.

This episode is 64:04 long.

This episode was published on Apr 28, 2026.

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