745: Why You’re Wired, Tired, and Awake at 3AM (And What to Do About It) with Dr. Scott Sherr

Why are so many women waking up exhausted… but unable to shut their brain off?” In this episode, Dr. Mariza sits down with Scott Sherr to unpack the hidden nervous system and biochemical shifts driving sleep struggles, anxiety, exhaustion, and feeling “wired and tired” in midlife. Together, they explore why women in perimenopause often lose stress resilience, why the brain gets stuck in overdrive at night, and how neurotransmitters like GABA, serotonin, adenosine, and cortisol shape sleep quality, recovery, and mood. They also dive into the powerful connection between mitochondrial health, nervous system regulation, energy production, and why building more “reserve” may be the missing key to feeling calm, focused, and resilient again. If you’ve been struggling with middle-of-the-night wakeups, burnout, anxiety, or feeling like your brain never truly powers down, this episode will help connect the dots—and offer practical solutions that actually move the needle. Dr. Scott Sherr Dr. Scott Sherr is a physician, health optimization expert, and Chief Operating Officer of Troscriptions. His work focuses on nervous system regulation, mitochondrial health, hyperbaric medicine, sleep optimization, and performance medicine. He is passionate about helping people improve resilience, energy, recovery, and cognitive performance through science-backed strategies and targeted support. IN THIS EPISODE Why so many women feel “wired and tired” in perimenopause The real reason behind 2–3 AM wakeups and racing thoughts How GABA, cortisol, serotonin, and adenosine impact sleep and stress Why nervous system regulation is essential for resilience and recovery The connection between mitochondrial health, energy, and brain function How chronic stress and sympathetic overload affect hormones and mood Practical tools to support sleep, focus, calm, and nervous system balance QUOTES “Sleep will make or break you the next day—especially in this season of life.” “To increase your performance is having more reserve.” “You’re not meant to live in a state of disruption, exhaustion, and feeling wired and tired all the time.” RESOURCES MENTIONED Use code ENERGIZED and get 10% off on your Troscription Order Use code ENERGIZED and get 10% off on your MitoQ Order Troscriptions Website Dr. Scott Sherr Instagram Dr. Scott Sherr Youtube RELATED EPISODES 744: The Midlife Brain Reset: How to Protect Your Memory, Focus & Mental Sharpness Starting Now 717: “I Don’t Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 728: Why Brain Fog Isn’t Random: The Hormone Shift Behind It 593: Why EVERYONE Needs Progesterone in Perimenopause & Beyond with Carol Petersen

You can listen to 745: Why You’re Wired, Tired, and Awake at 3AM (And What to Do About It) with Dr. Scott Sherr online on Radio and Podcast. Open the player on this page to stream the available audio.

745: Why You’re Wired, Tired, and Awake at 3AM (And What to Do About It) with Dr. Scott Sherr is an episode from Essentially You: Empowering You On Your Health & Wellness Journey With Safe, Natural & Effective Solutions by Dr. Mariza Snyder.

This episode is 70:53 long.

This episode was published on May 12, 2026.

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