Targeting the MLL Complex in Leukemia

Scott A. Armstrong, M.D., Ph.D., of the Dana-Farber Cancer Institute, studies how certain aggressive forms of acute myeloid leukemia (AML) develop and survive. His work centers on a protein called menin, which helps leukemia cells keep cancer-promoting genes switched on. Armstrong’s team has found that blocking menin with specially designed drugs can shut down these gene programs, push leukemia cells to mature, and slow or stop the disease in lab models and patients. While some leukemias adapt by developing mutations in menin or finding other ways to survive, his research is revealing why certain genes are especially dependent on menin and how to target them more effectively. These discoveries are now shaping new treatments, drug combinations, and potential strategies for other cancers that rely on similar mechanisms. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40875]

You can listen to Targeting the MLL Complex in Leukemia online on Radio and Podcast. Open the player on this page to stream the available audio.

Targeting the MLL Complex in Leukemia is an episode from Winning the War on Cancer (Audio) by UCTV.

This episode is 00:58:44 long.

This episode was published on Oct 1, 2025.

Yes. Use the heart button on the episode page to add it to your favorite episodes list.

Yes. This page shows related episodes from Winning the War on Cancer (Audio) when more episodes are available from the podcast feed.