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Understanding Childhood Cancer with Dr Geoff.
CAR T-cell therapy is an exciting new treatment for acute leukaemia. In this episode, Dr Geoff interviews his colleague Dr Caroline Bateman...
There is a special subtype of neuroblastoma seen in very young children, with spread of disease throughout the body, but which needs a very...
Childhood cancer treatment leads to severe impairment of the ability to fight infections. This episode explains what immune suppression mean...
A few years ago I described CAR T-cells, but they weren't available for routine use. I now update things, with the very important news about...
We take a lot of blood samples looking for infection in the bloodstream. This episode explains what blood cultures are all about. Hosted on...
A number of countries have research studies where childhood cancers are analysed in great detail, testing all the DNA in something called 'm...
The MEK inhibitors are a newer class of drug, and include trametinib, selumetinib and others. They have an important role in paediatric onco...
Sophisticated techniques can detect one cancer cell amongst a million normal cells. This episode describes these methods and how they are us...
For many years we didn't biopsy the tumour when the scans suggested that the tumour was a DIPG. This episode explains why that has changed,...
DIPG is a type of brain tumor which occurs in children. This episode explains what the letters mean. Hosted on Acast. See acast.com/privacy...
Ifosfamide is another chemotherapy drug, used particularly in certain sarcomas and certain patients with leukaemia. This episode explains ho...
We often need to evaluate heart function during chemotherapy. This episode explains what the tests are, and why we need to do them. Hosted o...
At the American Society of Clinical Oncology meeting in June 2016, a study was presented looking at using two autologous bone marrow transpl...
In this episode I read out for you an article written by Dr Susan Cohn from the University of Chicago. Dr Cohn is an eminent paediatric onco...
When families find themselves in a hospital, they meet all sorts of doctors with all sorts of titles, residents, interns, fellows, registrar...
Chemotherapy can make the white blood cell count drop, predisposing to infection. These drugs work to boost white blood cell production. Hos...
I talked about MIBG scans previously. In this episode I discuss the use of high doses of MIBG as a treatment of neuroblastoma. Hosted on Aca...
Adolescents and Young Adults with Cancer: What's special about the AYA's? by Dr Geoff Hosted on Acast. See acast.com/privacy for more inform...
MIBG scans are used to evaluate and monitor neuroblastoma. Hosted on Acast. See acast.com/privacy for more information.
My Christmas Special episode. Includes the Top 12 people who deserve a Christmas present more than the oncologist. Hosted on Acast. See acas...
Parents always ask why their child developed cancer. They ask if it is genetic, meaning is it something hereditary, or some abnormality in t...
There are multiple ways to go looking for DNA, RNA and protein abnormalities. Many should still be considered research, not standard practic...
Lymphomas make up about 11% of childhood cancer, and there are several different types. Hosted on Acast. See acast.com/privacy for more info...
There's multiple ways the DNA code can get messed up and lead to cancer. This episode describes some of them, along with some little green m...
The proteins have to have the right amino acids all assembled in the right order, and the DNA code is the recipe that's used. This episode e...
To understand all this DNA analysis business, first one needs to know a bit about proteins. Proteins basically do all the work in cells, and...
Gliomas are a type of brain tumour, and are usually called 'low grade' or 'high grade'. What do these terms mean? Hosted on Acast. See acast...
Some chemotherapy drugs don't get into the brain and spinal fluid properly, so we have to inject drugs into the spinal fluid. This is mainly...
We often need to take samples of the spinal fluid, and regularly inject chemotherapy drugs there too. We do this using a lumbar puncture. Ho...
When eating and nasogastric feeding aren't working, we may need to give nutrition straight into the vein. That's called TPN or hyperalimenta...
There's a lot of discussion about 'personalised medicine'. What is personalised oncology? Hosted on Acast. See acast.com/privacy for more in...
If children just can't eat enough, we may need a feeding tube. This episode explains what these tubes are all about. Hosted on Acast. See ac...
If nutrition is so important, then what food should kids eat while on chemotherapy? Hosted on Acast. See acast.com/privacy for more informat...
Children on chemotherapy can really struggle to maintain their weight. This episode explains why. Hosted on Acast. See acast.com/privacy for...
Exciting new antibodies against cancer were reported at ASCO this year. This episode explains how they work. Will they end up useful in chil...
The doctors and nurses keep raving on about fevers, not cancer.... what's this all about?This information may be life-saving. Hosted on Acas...
Most new drugs for cancer are first evaluated in adult patients, then we wait, and wait for access for children. The Europeans appear to hav...
High dose methotrexate is used in leukaemia, lymphoma, osteosarcoma and certain brain tumours. We give a sky-high dose, then give the antido...
Phase 3 trials are the big studies that compare a new treatment to the existing standard treatment. They enrol lots of patients and take yea...
How do we decide what clinical trials to open at a given institution? Hosted on Acast. See acast.com/privacy for more information.
Why I took two days off, and why kids on chemo should go to school (usually) by Dr Geoff Hosted on Acast. See acast.com/privacy for more inf...
Platelets are tiny little cells that make blood clot properly. They go low after chemotherapy sometimes, and we often end up giving a platel...
We rely on central lines enormously, but they can bring their own problems. This episode describes the common things that can go wrong with...
We often have to give blood transfusions following chemotherapy. This episode explains why we end up needing transfusions, when we give them...
AML requires chemotherapy treatment, and sometimes bone marrow transplantation. Hosted on Acast. See acast.com/privacy for more information.
We use phase 2 trials to conduct an initial evaluation of whether a new therapy has activity against cancer or leukaemia. This episode descr...
Phase I trials are the studies we do to work out the safety and dosing of new drugs. This podcast explains how they are conducted in adults...
Clinical trials are core business in childhood cancer units. It is through clinical trials that we have worked out what treatments are effec...
This episode describes the two types of central lines that are generally used in children receiving chemotherapy. Hosted on Acast. See acast...
Acute myeloid leukaemia is the second main form of leukaemia in childhood. This podcast explains what the disease is, and the tests and trea...