632: The science of skin aging & how to slow it down Saranya Wyles, M.D., Ph.D.

“Skin is our most visible biomarker of how we're aging on the inside,” explains Saranya Wyles, M.D., Ph.D. Wyles, a dermatologist, regenerative medicine scientist, and the director of the Regenerative Dermatology & Skin Longevity Lab at the Mayo Clinic, joins us today to unpack how the skin reflects systemic aging and the emerging therapies shaping the future of regenerative dermatology. - The skin’s connection to longevity (~3:45) - Markers of skin aging (~5:20) - Senescent cells & systemic aging (~6:35) - 5 pillars of skinspan (~8:25) - How to eat for better skin (~10:20) - The role of exercise (~12:30) - The best topicals (~13:55) - Sunscreen & morning sunlight exposure (~17:05) - What are peptides (~20:20) - Lasers & longevity (~25:20) - Procedures to be mindful of (~32:40) - Underrated skin habits (~33:35) - The future of skin longevity (~35:15) - Cognitive function & skin health (~39:50) - Hair loss (~42:30) Referenced in the episode: - Follow Wyles on Instagram (@drwyles.derm) - Check out her research ( - The Baltimore Longitudinal Study of Aging ( - Participate in the Skin Aging And Longevity Understanding Database (SALUD) ( We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

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632: The science of skin aging & how to slow it down Saranya Wyles, M.D., Ph.D. is an episode from The mindbodygreen Podcast | motivational interviews covering health, fitness, nutrition, entrepreneurship, self-help and more by mindbodygreen.

This episode is 48:26 long.

This episode was published on Jan 11, 2026.

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