Ep. 117: “The Pathogenesis of Viruses and Cancer” Featuring Dr. Matteo Iannacone

Guest: Professor Matteo Iannacone is Director of the Division of Immunology, Transplantation and Infectious Diseases, Professor of Pathology, and Head of the Dynamics of Immune Responses laboratory at Vita-Salute San Raffaele University. His work centers on understanding the generation of dysfunctional adaptive immune cells in chronic hepatitis B virus infection and developing new strategies to reprogram them into functional cells endowed with potent antiviral activity. Featured Products and Resources: Stay up-to-date with the latest in human immunology news I solate highly purified immune cells from virtually any sample source with EasySep The Immunology Science Round Up The Cells That Keep Immunity in Check – Brenda reviews Dr. Shimon Sakaguchi’s seminal study demonstrating that a population of T cells expressing the IL-2 receptor α chain acts to maintain self-tolerance by suppressing other T cells. The Gene That Controls Immune Balance – Brenda reviews Dr. Mary Brunkow and Dr. Fred Ramsdell’s work identifying FOXP3 as the gene disrupted in a fatal lymphoproliferation syndrome in the “scurfy” mouse, pointing to FOXP3 as a master regulator of regulatory T cells. Zap70 and the T reg Cell Repertoire – Age-dependent Zap70 expression regulates negative selection and thymic T reg cell development. T Cell Exhaustion Driven by Protein Stress – Researchers show that proteotoxic stress, induced by protein aggregation, is not merely a consequence, but a driver of the exhausted T cell state. Image courtesy of Professor Matteo Iannacone.

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Ep. 117: “The Pathogenesis of Viruses and Cancer” Featuring Dr. Matteo Iannacone is an episode from The Immunology Podcast by The Immunology Podcast.

This episode is 1:13:06 long.

This episode was published on Oct 21, 2025.

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