E131: A Sham-Controlled Sham of a Trial: RESET-RA

Today I cover the recent publication of the RESET-RA study, which evaluated vagal nerve stimulation to treat rheumatoid arthritis. Have a listen in full, but let me be clear upfront: I do not think this works and will not be referring any patients to receive it. This will forever be my pivotal example of the effect of unblinding, but would love to hear if you think different! Paper: Supplement (see S4):

You can listen to E131: A Sham-Controlled Sham of a Trial: RESET-RA online on Radio and Podcast. Open the player on this page to stream the available audio.

E131: A Sham-Controlled Sham of a Trial: RESET-RA is an episode from The Evidence Based Rheumatology Podcast by Michael Putman.

This episode is 14:48 long.

This episode was published on Jan 21, 2026.

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