Choosing and Interpreting PROs and COAs – A Guide for Clinical Trial Statisticians

In this episode, I sit down with Rachael Lawrance to dive into a topic that has become absolutely central to clinical research: patient-centered outcomes. When I first started as a statistician, I knew these measures existed—but I didn’t really understand how they were developed, analyzed, or used in decision-making. That has changed dramatically over the years. Today, patient-reported outcomes (PROs) and the broader framework of clinical outcome assessments (COAs) play a key role in regulatory approvals, payer decisions, and how we demonstrate treatment value. Rachael brings deep expertise from her work at Adelphi Values and shares how these endpoints are developed, validated, and applied in practice. We also discuss how statisticians can contribute more effectively by understanding the science behind these measures—not just treating them as “just another scale.”

You can listen to Choosing and Interpreting PROs and COAs – A Guide for Clinical Trial Statisticians online on Radio and Podcast. Open the player on this page to stream the available audio.

Choosing and Interpreting PROs and COAs – A Guide for Clinical Trial Statisticians is an episode from The Effective Statistician - in association with PSI by Alexander Schacht and Benjamin Piske, biometricians, statisticians and leaders in the pharma industry.

This episode is 41:26 long.

This episode was published on Apr 17, 2026.

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