#567: Personal AI Agents for Pythonistas
The most popular Python project you've probably never heard of has 252,000 GitHub stars and merged over 1,800 pull requests in a single week...
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Talk Python To Me - Python conversations for passionate developers
Talk Python to Me is a weekly podcast hosted by Michael Kennedy. The show covers a wide array of Python topics as well as many related topics (e.g. MongoDB, AngularJS, DevOps).The format is...
Episodes
20 of 566 episodes#566: State of the art in Python 2026
Which of your Python tools would you still pick if you started fresh today? For a long time, the answer was easy. The stack felt settled. AI...
#565: Tachyon, Python 3.15's Built-in Sampling Profiler
Do you know what's actually slow in your Python app? Or are you guessing? Until now, profiling Python meant a tracing profiler that made you...
#564: EVE Online Departs for Python 3
Every ship in EVE Online eventually undocks and leaves the station. This time, it's the whole game. EVE has run on Python 2 since it launche...
#563: Getting Started with Rust as Python Devs
Lint the entire CPython code base from scratch. It takes 0.3 seconds. Three blinks of an eye. That is ruff, and it is written in Rust. So ar...
#562: DuckLake: The Lakehouse That's Just SQL and Parquet
How many files does your query read before it reads any data? On some data lakes, you go through JSON and metadata files first, just to lear...
#561: TonIO, a Multi-threaded Async Runtime for Python
How many cores does your machine have, 10, 18? Your async Python code uses just one of them. That isn't a bug in asyncio. That's the design,...
#560: Building a Research OS: From Django to 30,000 Samples
In 2020, a gastroenterologist in Glasgow did the math on his new research study and came up with 30,000 samples, arriving over two years fro...
#559: 12 Things You Should (and Shouldn't) Do in AWS
Your site is down. It's 3am. Is it a bug, a bill, or a breach? You can't tell yet, and everyone is watching you find out. Matt Lea has spent...
#558: Hyper-Personal Software with Python
Every company has one. The little internal tool that Jane built back in 2021, and then Jane left. Nobody understands it, nobody will touch i...
#557: Security of everything at PyCon 2026
Security has always been the vegetables of software. Everyone agrees it matters, and somehow it never quite makes it onto the plate. At PyCo...
#556: Updates on Django's Async Story
For years, "Django and async" came with an asterisk. The docs themselves warned you off it. Scary performance notes, a story that felt half-...
#555: Marimo Pair - A Canvas for Agent + Developers Collaboration
Coding agents have gotten really good at one kind of work. You scope a feature, edit some files, run the tests, ship it. It all happens on d...
#554: Trustworthy AI in Healthcare and Longevity
You ask an AI a question and it answers with total confidence. Most of the time, a confidently wrong answer is just an annoyance. But what i...
#553: All of our tools
This episode is a fun crossover from our Python news and tips podcast, Python Bytes. We have had some big changes over there. Brian Okken ha...
#552: Astral joins OpenAI
OpenAI just acquired Astral, the company behind uv, Ruff, and ty. And if your first thought was "wait, is uv toast?", you are not alone. But...
#551: Stroll Down Startup Lane - 2026
If you've ever been to PyCon, you know one of the best parts of the expo hall is Startup Row, a stretch of booths where early-stage companie...
#550: AI Contributions and Maintainer Load in Open Source
You wake up, brew the coffee, open GitHub, and there it is. Another pull request on your open source project. Thirteen thousand lines added....
#549: Great Docs
Your documentation has two audiences now - humans reading the rendered HTML, and AI agents trying to make sense of your library. Rich Iannon...
#548: Event Sourcing Design Pattern
What if your database worked more like Git? Every change captured as an immutable event you can replay, instead of a single mutating row tha...