Desperately Seeking Rosanna… Arquette

Rosanna Arquette has been working in Hollywood for nearly five decades, and she’s got stories from every era of the business! She talks about growing up in the legendary Arquette family surrounded by artists, musicians, and activists, and how that led to her first roles and an early Emmy nomination for The Executioner’s Song. She shares behind-the-scenes stories from Desperately Seeking Susan, including Madonna’s rise to superstardom during filming, and what she learned from Martin Scorsese on After Hours and Quentin Tarantino on Pulp Fiction. Rosanna also reveals what it was like working with David Bowie on The Linguini Incident, how she landed roles without auditioning, and why she still doesn’t watch most of her own movies. She talks about directing her documentary Searching for Debra Winger, navigating Hollywood as a working actress for over 40 years, and how the business has changed from in-person auditions to zoom calls. Plus, she discusses her latest projects, filming in Canada, and the next generation of Arquettes carrying on the family legacy. Thank you for supporting our sponsors! Tellus: Learn more at or search Tellus in the Apple App Store or Android Store. Talk Is Jericho is available on YouTube! Don’t forget to Like,

You can listen to Desperately Seeking Rosanna… Arquette online on Radio and Podcast. Open the player on this page to stream the available audio.

Desperately Seeking Rosanna… Arquette is an episode from Talk Is Jericho by Chris Jericho.

This episode is 47:43 long.

This episode was published on Mar 27, 2026.

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