Mitochondrial Function and Energy Resilience in Clinical Practice with Mitokatlyst S. Dugar PhD

In this episode of the Innovations and Clinical Implementation podcast, hosts Dr. Lexi Gonzales and Tom Blue interview Dr. Sundeep Dugar, a pharmaceutical drug hunter with nearly 40 years of experience in small molecule discovery who serves as the co-founder and Chief Scientific Officer at Blue Oak Nutraceuticals. The conversation focuses on the development of Mitocatalyst, a precision-formulated epicatechin designed to mimic the mitochondrial biogenesis normally triggered by exercise. Dr. Dugar reveals his breakthrough discovery that exercise-induced Reactive Oxygen Species (ROS) signal the mitochondria to produce a specific steroid—11-beta hydroxyprogesterone—and explains how Mitocatalyst utilizes nanomolar doses of epicatechin to molecularly mimic this steroid, distinguishing it from high-dose antioxidant protocols that paradoxically blunt these beneficial signals. The discussion uses the metaphor of building a "fireplace" (mitochondria) to burn "firewood" (nutrition), positioning the supplement as a critical intervention for aging patients or those unable to exercise. For access to episode resources:

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Mitochondrial Function and Energy Resilience in Clinical Practice with Mitokatlyst S. Dugar PhD is an episode from Redefining Medicine by A4M.

This episode is 25:00 long.

This episode was published on Jan 30, 2026.

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