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From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD artwork
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From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD

Redefining Medicine by A4M

Feb 10, 202627:02Health

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores the intersection of AI and gut health with Dr. Helen Messier, a physician and molecul...

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From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD is an episode from Redefining Medicine by A4M. In this episode of the Innovations and Clinical...

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Published Feb 10, 2026, 27:02 long, audio available.

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What is From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD about?

In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores the intersection of AI and gut health with Dr. Helen Messier, a physician and molecular immunologist who serves as the Chief Medical and Science Officer at Fountain Life; Dr. Leo Grady, the founder of Jona and an AI expert who previously led the team achieving the first FDA approval for an AI product in pathology; and Dr. Lawrence Kosinski, a gastroenterologist and founder of Sonar MD who is a national leader in value-based care. The panel discusses how Jona's AI platform processes over 220,000 studies to identify dysbiotic patterns that antedate clinical disease—ranging from metabolic liver disease and colon polyps to Parkinson's and cardiovascular issues linked to TMAO—thereby moving clinical focus from "symptoms to systems". The experts emphasize the mechanism of the gut-brain axis, noting that metabolites like butyrate derived from soluble fiber are essential for stabilizing the blood-brain barrier and DNA, while warning that popular GLP-1 agonists, though effective for weight loss, can "collapse" microbiome diversity and require careful monitoring. For access to episode resources, click HERE .

Where can I listen to From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD?

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Which podcast is From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD from?

From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD is an episode from Redefining Medicine by A4M.

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This episode is 27:02 long.

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This episode was published on Feb 10, 2026.

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Where can I listen to From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD?

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Which podcast is this episode from?

From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD is from Redefining Medicine by A4M.

What are the episode details?

Published Feb 10, 2026 and 27:02 long