Antiarrhythmic Drugs Part 2

In this episode, we are going to review antiarrhythmic drugs that clinicians may encounter in practice: Digoxin, Propafenone, Dofetilide, and a few others. While these drugs are commonly used in the management of atrial fibrillation and other rhythm disturbances, they each come with important pharmacology and safety considerations that pharmacists and healthcare providers need to recognize. Digoxin is a cardiac glycoside that increases contractility while also slowing AV node conduction through enhanced vagal tone, making it useful for rate control in atrial fibrillation, particularly in patients with heart failure. However, it has a narrow therapeutic index, and toxicity can occur if renal function declines or electrolyte abnormalities develop. Propafenone is a Class IC sodium channel blocker used primarily for rhythm control in atrial fibrillation. A key clinical pearl with this medication is that it should generally be avoided in patients with structural heart disease due to the risk of proarrhythmia. Dofetilide and sotalol are both Class III antiarrhythmics that work by blocking potassium channels and prolonging cardiac repolarization. Because of their ability to prolong the QT interval, both agents carry a risk of torsades de pointes and require careful monitoring. Dofetilide initiation typically requires hospitalization to monitor the QT interval and adjust dosing based on renal function. Sotalol also requires attention to renal function and ECG monitoring, and it has additional beta-blocking effects that can contribute to bradycardia and fatigue. Throughout this episode, we will break down the mechanisms, common clinical uses, and key safety pearls for these medications to help you better understand how they fit into arrhythmia management. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

You can listen to Antiarrhythmic Drugs Part 2 online on Radio and Podcast. Open the player on this page to stream the available audio.

Antiarrhythmic Drugs Part 2 is an episode from Real Life Pharmacology - Pharmacology Education for Health Care Professionals by Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist.

This episode is 14:00 long.

This episode was published on Mar 12, 2026.

Yes. Use the heart button on the episode page to add it to your favorite episodes list.

Yes. This page shows related episodes from Real Life Pharmacology - Pharmacology Education for Health Care Professionals when more episodes are available from the podcast feed.