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Joe and Andrew discuss and often QUESTion topics in medicine.
Donato J, et al. Things We Do For No Reason™: Low salt diets for patients with acute heart failure. J Hosp Med 2026 Feb 4; [e-pub]. DOI: 10....
432. CME LECTURE- Under Pressure, Blood Pressure
https://www.sciencedirect.com/science/article/abs/pii/S2665991326000342?via%3Dihub lancet rheumatology A treat-to-target strategy versus sym...
Let’s rewind to the early 2000s. Flip phones were cool, low-rise jeans were a crime, and the Women’s Health Initiative—WHI—dropped what beca...
— rivaroxaban versus apixaban. Yes, folks, this is The Battle of the Blood Thinners! And spoiler alert — one of them came out looking like t...
Minocycline in Acute Ischemic Stroke (EMPHASIS trial) A multicenter, double-blind RCT in China studied 1,724 patients with acute ischemic st...
Today, we're talking about Kawasaki disease-no, not the motorcycle company, though sometimes treating it does feel like trying to ride one a...
Setting the stage Picture this: your knee is like a three-room apartment. You've got a medial room, a lateral room, and a patellofemoral roo...
Kalapura C, et al. Triptan initiation and cerebrovascular events in patients with migraine: A nationwide cohort study. J Am Heart Assoc 2026...
Li H-Y, et al. GLP-1 receptor agonists and risk of optic nerve or vision-threatening events in patients with type 2 diabetes or cardiometabo...
CME-- Discharge Questions Answered in 2025
Lin Z, et al. Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency. Science 2026 Feb 5; 391:eadz4075. DOI: 10....
Stavropoulou E, et al. Reassessing the 2023 International Society for Cardiovascular Infectious Diseases Duke clinical criteria for infectiv...
we look at CODE LVO and what does being frail even mean????? vaccines may not help baby and antibiotics still don't help viral illness
CME song --Check the Lytes
CME - sodium, potassium, calcium
10.1016/j.jaip.2025.07.005 .40675327 All of the videos were found to be useful or very useful, 99% were of moderate or high reliability, and...
Wolfe R, Broder JC, Zhou Z, et al. Aspirin, cardiovascular events, and major bleeding in older adults: extended follow-up of the ASPREE tria...
Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction - https://www.nejm.org/doi/full/10.1056/NEJMoa2504735?query=WB M...
https://pubmed.ncbi.nlm.nih.gov/40767818/ This is a great example for students and residents to look and see that the abstract does not alwa...
Efficacy and safety of Baxdrostat in uncontrolled and resistant hypertension compared to placebo in phase three when there are MRA available...
gabapentin may increase COPD exacerbations Benzo for ETOH might be long gone..guess what is going to replace it Anticoagulation after ablati...
Clinicians should refer patients for liver transplant evaluation after any decompensation event —such as ascites or variceal bleeding— regar...
Study Summary: Emergent Carotid Stenting in Acute Stroke Thrombectomy A multicenter registry study in Catalonia (2017–2023) evaluated outcom...
This massive meta-analysis of 484 randomized, double-blind, placebo-controlled trials (104,176 participants) quantified the blood pressure–l...
Practice Pearls: “Skip Leg Day” (Sometimes) For PAD patients who can’t tolerate leg workouts, upper body aerobic training is a strong, evide...
GLP1 drugs work but they likely need lifestyle modifications No convincing evidence GLP1 cause thyroid cancer in humans BUT contraindication...
OMED COPD CME
All of these articles have been talked about on questioning medicine social media on tik tok and instagram but here is an update of my recen...
Buelt, Andrew | 2:13 PM (1 hour ago) | | to me https://jamanetwork.com/journals/jama/fullarticle/2833338 Conclusions and Relevance These res...
https://www.nejm.org/doi/10.1056/NEJMoa2504544 During follow-up ranging from 12 to 52 weeks, fewer patients had severe exacerbations in the...
https://publications.aap.org/pediatrics/article/156/1/e2024070175/202234/Infant-Antibodies-After-Maternal-COVID-19?autologincheck=redirected...
https://www.nejm.org/doi/10.1056/NEJMoa2415879?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Key Findings: Cla...
GLP1 might cause thyroid cancer in mice but the evidence is drastically lacking in humans Oral semaglutide is expensive for an NNT of 50 at...
https://jamanetwork.com/journals/jama/article-abstract/2834040 amiloride is realistically equal to spironolactone for resistant HTN https://...
https://www.jthjournal.org/article/S1538-7836(25)00109-6/fulltext Antithrombotic agents, like aspirin and anticoagulants, are essential for...
https://jamanetwork.com/journals/jama/article-abstract/2834632 Summary The article examines the effectiveness and safety of zilebesiran, an...
https://www.nejm.org/doi/full/10.1056/NEJMoa2405182?query=recirc_Semantic Key Takeaways Extended Predictive Value of Biomarkers : High-sensi...
Desgagnés N et al. Use of albumin-adjusted calcium measurements in clinical practice. JAMA Netw Open 2025 Jan 21; 8:e2455251. ( https://doi....
https://www.nejm.org/doi/10.1056/NEJMoa2416394 At 72 weeks, the mean percentage decrease in weight was significantly greater with tirzepatid...
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2832701 In this multisite trial, 800 adults who smoked 10 or more cigarett...
What does the evidence and the guidelines say about the use and testing of Vitamin D in kids
Aryee EK et al. Prevalence of obesity with and without confirmation of excess adiposity among US adults. JAMA 2025 Apr 17; [e-pub]. ( https:...
In an hour-by-hour analysis, patients we suspect to have asthma are significantly more likely to have positive bronchodilator responses earl...
Vitamin D and Adults and what you should do with Vitamin D
a cme lecture on the outpatient management of COPD
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