CREB5: A Master Regulator of Stem Cell-Like Programs in Prostate Cancer Progression

Androgen receptor (AR) signaling has long been the central driver of prostate cancer progression and the primary target of therapies for advanced disease. Yet, a significant subset of tumors either fail to respond or develop resistance, often by switching to AR-independent programs that resemble basal or stem cell-like states. Understanding what drives these aggressive, therapy-resistant phenotypes is a critical challenge in oncology. A research paper, titled “CREB5 regulates stem cell-like transcriptional programs to enhance tumor progression in prostate cancer” was published in Volume 17 of Oncotarget by a multi-institutional team of researchers, identifies a key molecular regulator of this process and reveals how it promotes tumor progression. Full blog - Paper DOI - Correspondence to - Emmanuel S. Antonarakis - anton401@umn.edu, Justin Hwang - jhwang@umn.edu Abstract video - Sign up for free Altmetric alerts about this article -

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CREB5: A Master Regulator of Stem Cell-Like Programs in Prostate Cancer Progression is an episode from Oncotarget by Oncotarget Podcast.

This episode is 00:10:49 long.

This episode was published on Apr 7, 2026.

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