TB Trails and Tails

Why Tuberculosis is still the most deadly infectious disease. Attention, DNA detectives! We’ve got a rat on the loose – but don’t worry, not the snitching, double-agent kind. We’re talking about the whiskered, hyper-skilled, tiny agents who aren't snitching - they're sniffing out one of the world’s deadliest diseases: tuberculosis (TB). Tuberculosis might sound old-timey, but it’s still the globe’s top infectious killer– growing tougher, more drug-resistant, and hitting hardest where access to care falls short. So for our Season 5 finale, host Dr. Kaylee Byers digs into TB’s fascinating backstory, and teams up with microbiologist Dr. Jennifer Guthrie to figure out why this ancient disease still has such a tight grip, and how genomics is helping track its every move. Along the way, Dr. Zolelwa Sifumba shares her story as a multidrug-resistant TB survivor, and how her treatment journey fuels her advocacy today. Buckle up: this investigation has it all : science, politics, global inequities… and a squad of extraordinary rats. Special thanks to APOPO for sending us field recordings and interviews from their HeroRAT training program. Highlights (3:42) The history of TB (8:19) Why TB sits at the top of the global disease podium (15:30) Meet Zolelwa - a multi-drug-resistant TB survivor (30:48) The power of education – Show Notes/Resources: 1. Giant Rats Trained to Sniff Out Tuberculosis in Africa - National Geographic 2. The Making of a HeroRAT: From Tiny Pup to Life-saving Hero - APOPO 3. Tuberculosis: an ancient disease that remains a medical, social, economical and ethical issue - Journal of Preventive Medicine and Hygiene 4. History of World TB Day - CDC 5. The history of tuberculosis - Respiratory Medicine 6. Chapter 12: An introductory guide to tuberculosis care to improve cultural competence for health care workers and public health professionals serving Indigenous Peoples of Canada - Canadian Journal of Respiratory, Critical Care, and Sleep Medicine 7. Everything is Tuberculosis - John Green

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TB Trails and Tails is an episode from Nice Genes! by JAR Audio.

This episode is 35:08 long.

This episode was published on Dec 16, 2025.

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