Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
Problematic alcohol use frequently occurs in conjunction with anxiety disorders. Between 20 to 40 percent of individuals with anxiety disord...
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Neuropsychopharmacology Podcast
BrainPod is the podcast from the journal Neuropsychopharmacology, produced in association with Nature Publishing Group. Join us as we delve into the latest basic and clinical research that a...
Episodes
20 of 67 episodesExamining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia
Insomnia and depression are two serious and debilitating conditions. Insomnia on its own is linked to an increase in suicide risk, and insom...
Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats
There are a number of theories that have been studied to try to explain addiction and drug use escalation, and thus to also create animal mo...
Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles
Oxytocin has become known for having anti-anxiety and affiliative behavioral effects. That’s why clinicians and researchers are excited abou...
The genetics of cannabis lifetime use
Cannabis, which is increasingly legally available, both for therapeutic and recreational use, is now one of the most commonly used drugs wor...
Older and wiser? The neural correlates of worry induction and reappraisal in older adults
Worry seems like something most people do from time to time, but for some people, severe worry can become an overwhelming sensation, and for...
Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls
There’s been a fair amount of animal data suggesting that nicotine can affect the developing brain, but there hadn’t been the equivalent hum...
Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records
Attention deficit hyperactivity disorder, or ADHD, is a common condition that, for a lot of people, is difficult to treat. The drugs that ex...
Rapid and sustained antidepressant effects of vaporized N,N-Dimethyltryptamine: A Phase 2a clinical trial in Treatment-Resistant Depression.
Draulio Araujo, professor at the Brain Institute in the University of Rio Grande Norte in Natal, Brazil, has been studying ayahuasca for mor...
Endocannabinoid contributions to the perception of socially relevant, affective touch in humans
New drugs that target the endocannabinoid system are being proposed for disorders that are usually characterized by the dysregulation of soc...
Sex differences in sensitivity to dopamine receptor manipulations of risk-based decision making in rats
The scientific literature has shown that females demonstrate more aversion to risk-taking than males. Studies have also demonstrated that th...
Biomarker development for menstrual Cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity.
The menstrual cycle is known to affect things like mood and changes in pain. But there can also be symptoms that have a serious impact on a...
Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations
Researchers are interested in understanding the biology of why some people are more likely to overconsume substances. Some substances are di...
C-reactive protein moderates associations between racial discrimination and ventromedial prefrontal cortex activation during attention to threat in Black American women
Scientists have been amassing an increasing amount of evidence about the impact of racial discrimination and racial trauma, including how it...
Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial
There’s a hormone called ghrelin that’s secreted in the stomach, and when someone is hungry it contributes to that feeling of hunger and the...
Spotlighting SHAPERS: Sex hormones associated with psychological and endocrine roles
Dr. Nicole Petersen is an assistant professor in the department of psychiatry and behavioral sciences at UCLA. Her commentary is a new paper...
Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Serotonin is a critical chemical when it comes to a number of psychiatric conditions, such as OCD, where it seems to play a particular role...
Integrating public health and translational basic science to address challenges of xylazine adulteration of fentanyl
The drug naloxone, otherwise known as Narcan, is a critical tool in reversing fentanyl overdoses and reducing mortality. But now fentanyl is...
The why, when, where, how, and so what of so-called rapidly acting antidepressants
Sanjay Mathew is a professor and vice chair for research at Baylor College of Medicine and director of the Mood and Anxiety Disorders Progra...
AI-based analysis of social media language predicts addiction treatment dropout at 90 days
In-person treatment for substance use disorders is an incredibly important tool, but there’s a high failure rate — more than 50 percent of p...