163: The Clinical Reality of Seronegative Myasthenia Gravis

Welcome to the NeurologyLive ® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice. In this Mind Moments episode, Sarah Hoffmann, MD, PhD, senior neurologist at Charité – University Medicine Berlin, provides clinical insight into the evolving and often challenging landscape of seronegative generalized myasthenia gravis (gMG). Drawing from both clinical experience and research, Hoffmann discusses how seronegative MG is defined in the absence of detectable antibodies and why it represents a heterogeneous and often underrecognized subgroup of patients. The conversation explores key diagnostic challenges, particularly in patients with limb-predominant symptoms, where differentiation from other neuromuscular or functional disorders can be difficult. Hoffmann also reviews current treatment approaches, noting that while standard therapies mirror antibody-positive MG, access to targeted treatments remains limited. Additional discussion focuses on the barriers to advancing clinical trials in this population, the need for reliable biomarkers to better stratify patients, and the importance of continually reassessing diagnosis in nonresponders to avoid both undertreatment and overtreatment. Looking for more neuromuscular discussion? Check out the NeurologyLive ® Neuromuscular clinical focus page . Episode Breakdown: 1:15 – Defining seronegative MG and estimating prevalence within overall patient population 2:15 – Diagnostic challenges and distinguishing seronegative MG from mimics and functional disorders 5:35 – Role and limitations of antibody testing, electrophysiology, and pharmacologic response 6:50 – Neurology News Network 9:05 – Current treatment strategies and variability in access to targeted therapies 11:55 – Barriers to clinical trials and need for improved patient stratification methods 13:05 – Key unanswered questions including biomarkers and reassessing diagnosis in nonresponders The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: FDA Accepts Zilganersen New Drug Application for Priority Review in Alexander Disease FDA Grants Accelerated Approval to Tividenofusp Alfa for Neurologic Hunter Syndrome FDA Approves Higher Strength, More Effective Nusinersen Dose for Spinal Muscular Atrophy Thanks for listening to the NeurologyLive ® Mind Moments® podcast. To support the show, be sure to rate, review, and

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163: The Clinical Reality of Seronegative Myasthenia Gravis is an episode from NeurologyLive Mind Moments.

This episode is 16:56 long.

This episode was published on Apr 3, 2026.

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