Circulating Tumor Cells Dr. Dan Rubin Ryan Sternagel

show notes @ KEY TAKEAWAYS 1. What are CTCs and what do they mean? Cells from a collection of cancer cells, tumor or metastatic deposit Sometime seen on scans but not always Circulate in the blood or lymphatic tissues Can only test for the CTC in blood. Need biopsy to detect in lymphatic tissue The presence of CTCs doesn't necessarily indicate metastatic cancer CTCs don't live very long in the blood – persistent CTC is cause for concern Cancer spreads in two ways Metastasize (means "evil spread") - cells travel via blood vessels Direct invasion - cells invade the tissues and then access lymphatic system or blood stream What to look for in CTC testing Only available for certain cancers – ovarian, pancreatic, colon, lung, breast, prostate Looking for two different populations of CTCs- cytokeratin(CK)-positive and CK-negative ➔ CK is an anchor molecule for cells ➔ CK-negative cells are cells that have down regulated their CK and can leave the tissue space to 'circulate' as a CTC ➔ CK-positive cells are rarely found in CTC tests unless through trauma or if the tumor is invasive ➔ CK-negative cells can revert back to CK-positive and "anchor in" to a new tissue site Test results provide highly individual information about that person's specific tumor Can also see some markers you'd see on pathology specimens - things that sit on the surface of cells such as androgen and estrogen receptors Hosted By: 2. 3. 29 When to test for CTCs At diagnosis and before treatment, when cancer is the highest During treatment to gauge therapeutic response Post treatment testing to determine if cancer is still present or to identify recurrences What to do with CTC test results Depends on the patient – their history, the cancer, how aggressive, treatment proto- cols undertaken. Every situation/person is different Run other lab tests to look at supporting factors in the blood and fix those: ➔ Inflammatory markers ➔ Cell markers ➔ Immune markers ➔ Tissue markers ➔ Hormones ➔ Tissues at risk – liver, lung, bones ➔ Nutrient levels ➔ Vitamin D – 25-Hydroxy and 1,25-Dihydroxy ➔ Look at lifestyle – diet, toxins, air, water Goal is to shut down the flow of CTC into the blood CASE STUDIES / CLINICAL EXAMPLES / DIAGNOSES REFERENCED Breast cancer Colon cancer Lung cancer Ovarian cancer Pancreatic cancer Prostate cancer STUDIES / ARTICLES / CLINICAL TRIALS REFERENCED N/A BOOKS REFERENCED N/A Hosted By: 30 SUPPLEMENTS REFERENCED N/A THERAPIES REFERENCED IV Vitamin C IV Quercetin Mistletoe therapy OTHER RESOURCES Biocept FOLLOW DR RUBIN Listenandcare.com Aspenmedcenter.com PH: 480.990.1111 Remote consultations available

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Circulating Tumor Cells Dr. Dan Rubin Ryan Sternagel is an episode from My Kid Cures Cancer by Ryan Sternagel.

This episode is 57:01 long.

This episode was published on Jan 21, 2021.

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