The Orphan Drug Act in the Modern Drug Pricing Era

Kristi Martin, a longtime Washington, DC–based policy strategist with deep experience implementing major legislation like the Affordable Care Act and the Inflation Reduction Act, explores how the Orphan Drug Act, passed in 1983 as a bipartisan, patient-driven effort, transformed rare disease treatment by aligning scientific advances, government investment, and market incentives, but that reform may now be necessary—rethinking incentives for blockbuster drugs, refining orphan eligibility, and shifting toward more targeted, evidence-based negotiation.

You can listen to The Orphan Drug Act in the Modern Drug Pricing Era online on Radio and Podcast. Open the player on this page to stream the available audio.

The Orphan Drug Act in the Modern Drug Pricing Era is an episode from Managed Care Cast by Managed Care Cast.

This episode is 00:19:48 long.

This episode was published on Feb 3, 2026.

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