To RNase or Not to RNase: That Is the Question

Join Dr. Anna Wolska and Dr. Jim Posada as they delve into the intricacies of RNAse therapy in the management of Systemic Lupus Erythematosus (SLE). In this podcast episode, Dr. Posada describes the groundbreaking study evaluating the efficacy of RSLV-132, a novel RNAse molecule fused to human IgG1 Fc, in reducing chronic inflammation associated with cutaneous lupus. Key findings from the clinical trial reveal that patients with moderate to severe cutaneous disease activity were administered RSLV-132 over a span of six months. Disease activity was evaluated using the Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) score and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K). These findings suggest that RNAse therapy may be effective in patients with higher disease activity. Read the related paper in LSM -

You can listen to To RNase or Not to RNase: That Is the Question online on Radio and Podcast. Open the player on this page to stream the available audio.

To RNase or Not to RNase: That Is the Question is an episode from Lupus Science and Medicine podcast by BMJ Group.

This episode is 14:05 long.

This episode was published on Mar 4, 2024.

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