SCCMPod-558: The Future of Xenotransplantation

In this episode of the Society of Critical Care Medicine (SCCM) Podcast, host Diane C. McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, speaks with Muhammad Mansoor Mohiuddin, MD, MBBS, DSc (Hon), FAST, director of the Cardiac Xenotransplantation Program at the University of Maryland School of Medicine, about his Thought Leader presentation at the 2025 Critical Care Congress, The Remarkable Potential of Xenotransplantation , and his groundbreaking work on that subject. Dr. Mohiuddin discusses the need to address the global shortage of donated organs and the use of genetically modified pig organs as a viable solution. He explains the science behind xenotransplantation, including the use of CRISPR-Cas9 gene editing technology to delete immunogenic pig genes and insert human-compatible genes. The conversation explores the unique immunologic challenges of xenotransplantation, particularly antibody-mediated rejection and the need for tailored immunosuppression protocols. Ethical considerations include religious perspectives and public opinion. Dr. Mohiuddin emphasizes the importance of continued research funding and collaboration with industry partners to advance clinical trials and refine genetic modifications. Listeners will gain insight into how decades of research are transforming xenotransplantation and its potential to extend life and reshape the future of organ transplantation.

You can listen to SCCMPod-558: The Future of Xenotransplantation online on Radio and Podcast. Open the player on this page to stream the available audio.

SCCMPod-558: The Future of Xenotransplantation is an episode from iCritical Care: Critical Care Medicine by Society of Critical Care Medicine (SCCM).

This episode is 25:12 long.

This episode was published on Nov 26, 2025.

Yes. Use the heart button on the episode page to add it to your favorite episodes list.

Yes. This page shows related episodes from iCritical Care: Critical Care Medicine when more episodes are available from the podcast feed.