Episode 268: Everything ADCs in Cancer With Paolo Tarantino

Paolo Tarantino, MD, PhD, medical oncologist at Dana-Farber Cancer Institute, joins Chadi for a deep dive into the rapidly evolving world of antibody-drug conjugates (ADCs)—sometimes dubbed “super-chemotherapies.” He traces the fascinating origins of the ADC concept, including a centuries-old scientific insight that foreshadowed their development, and explains the biology behind how these targeted therapies deliver potent cytotoxics directly to cancer cells across tumor types. Dr. Tarantino also reflects on launching his career alongside the infancy of modern ADCs, explores innovations like multi-payload constructs, and weighs in on whether ADCs could ultimately replace conventional chemotherapy as research continues to push the field forward. Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. Watch all Healthcare Unfiltered episodes on YouTube.

You can listen to Episode 268: Everything ADCs in Cancer With Paolo Tarantino online on Radio and Podcast. Open the player on this page to stream the available audio.

Episode 268: Everything ADCs in Cancer With Paolo Tarantino is an episode from Healthcare Unfiltered by Chadi Nabhan.

This episode is 35:30 long.

This episode was published on Feb 24, 2026.

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