Replication of Bulky DNA Adducts

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06 by Ludwig-Maximilians-Universität München

Aromatic amines are known to be strong carcinogens. After metabolic activation, they react as electrophilic arylnitrenium ions with nucleophilic functionalities of the DNA duplex interfering and disrupting DNA and RNA sy...View more