Optimised plasmids for sustained transgene expression in vivo

Fakultät für Chemie und Pharmazie - Digitale Hochschulschriften der LMU - Teil 03/06 by Ludwig-Maximilians-Universität München

Plasmid based gene therapy approaches often lack long term transgene expression in vivo due to silencing or loss of the vector. One way to overcome these limitations is to combine non-silenced promoters with strong viral...View more