Your Best Shot: Holistic Approach to GLP-1

In this episode of The Evolution of Medicine, host James Maskell interviews registered dietitian Ashley Koff about her new book Your Best Shot. The conversation explores the seismic impact of GLP-1 agonists like Ozempic and Wegovy—and how functional medicine can pivot from a "weight loss" mindset to a "weight health" approach. Koff reframes these medications not as magic bullets, but as biosimilar hormone replacement tools that "switch on" receptor sites—without repairing the underlying ecosystem. She outlines a five-part Weight Health Hormone assessment and introduces a Physician–Dietitian–Health Coach triad to ensure sustainable outcomes. The episode challenges practitioners to stay "agnostic about the agonist" and instead focus on metabolic repair, patient education, and structured team-based care. About the Guest: Ashley Koff, RD is a registered dietitian and functional nutrition expert focused on metabolic health, personalized nutrition, and hormone signaling. She is the author of Your Best Shot and advocates for a "Weight Health" approach that integrates assessment, repair, and team-based implementation. Ashley Koff, RD Website: Instagram: Facebook: Linkedin: James Maskell Website: Instagram: Facebook: LinkedIn: Thank you for listening. Please

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Your Best Shot: Holistic Approach to GLP-1 is an episode from Evolution of Medicine Podcast by James Maskell.

This episode is 36:12 long.

This episode was published on Feb 23, 2026.

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