Cortisol Hormone Replenishment & Stress with Bryana Gregory, PharmD, RPh

Could low cortisol be the hidden reason behind chronic fatigue, poor stress tolerance, sleep disruptions, or mood changes? Cortisol is often misunderstood as just a “stress hormone,” but it plays a critical role in regulating energy levels, emotional resilience, inflammation, and the body’s natural sleep-wake cycle. When cortisol production becomes depleted due to prolonged stress, illness, or trauma, the body may struggle to function optimally, leading to symptoms commonly associated with adrenal insufficiency. Join us today as Bryana Gregory, PharmD, RPh, Pharmacist and Physician Liaison at Physicians Preference Pharmacy, explains how compounded oral cortisol can be used as a personalized hormone replacement option to support adrenal function. She walks through how cortisol naturally follows a diurnal rhythm, why low levels can disrupt sleep and energy, and how carefully dosed replacement may help restore balance. The discussion also highlights how compounded formulations allow for individualized dosing, cleaner ingredients, and delivery methods that better mimic the body’s natural cortisol patterns. Listeners will gain insight into who may benefit from cortisol replacement, how it differs from adrenal supplements, and why more is not always better when it comes to hormone therapy. This episode emphasizes the importance of working closely with a knowledgeable physician to address symptoms, monitor response, and create a customized approach that supports long-term wellness, resilience, and overall quality of life. To learn more, visit or call 281-828-9088. Watch now and

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Cortisol Hormone Replenishment & Stress with Bryana Gregory, PharmD, RPh is an episode from Dr. Hotze's Wellness Revolution by Dr. Hotze's Wellness Revolution.

This episode is 00:18:44 long.

This episode was published on Jan 28, 2026.

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