Radio and PodcastRadio and PodcastLive Radio & Podcasts
Depresh Mode with John Moe cover
Health

Depresh Mode with John Moe

Maximum Fun

Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, an...

Episodes

20 of 309 episodes

Mental Illness Before and After Pregnancy with Dr. Kara Zivin, Who Has Been There

Her memoir, Persevered, tells the story of a spiraling depression that nearly took her life

00:48:23Sep 21, 2026

Singer Nicole Atkins Doesn’t Recommend Insomnia, Alcoholism, Falling Down Sinkholes

Her new album, Drama, is full of songs that began as half-lucid mumbled ideas

00:47:08Sep 14, 2026

AI Chatbots Destroyed His Reality. Dr. Jeremy Heffner Explains Why He Believed Them.

The trauma surgeon and author of Proof of the Impossible details his descent to Wonderland.

01:03:54Sep 7, 2026

Best of Depresh Mode: Cameron Esposito on Comedy, Rehab, and Bipolar Disorder

The veteran standup comic makes sense of a post-diagnosis life and career.

00:44:45Aug 31, 2026

Cat Grief is Real. So is Human Grief. We’re Underestimating and Misunderstanding Both.

Cat Grief is Real. So is Human Grief. We’re Underestimating and Misunderstanding Both.

01:04:00Aug 24, 2026

Oh, It’s Autism, Mary H.K. Choi Learned at 43. Okay, She Thought, That Explains a Lot.

The author of the new novel Pool House finally found some explanation to decades of thoughts and actions.

01:07:13Aug 17, 2026

Margaret Glaspy Ends Her Instagram Addiction and Sings From Her Original Thought

The singer-songwriter’s new album I Am Both was made with clarity by a post-Instagram mind.

01:02:29Aug 10, 2026

Depression, Loneliness, and Memory Problems Are Worse In Middle Age, But Only in America

Unpacking troubling data (for Yanks) with researcher Frank Infurna, plus a Mike Doughty update.

00:49:39Aug 3, 2026

Codependency and Covid on a Tiny Boat in the Middle of the Ocean, with Angela Harger-Thompson

The author of Worst Tits Ever recounts trauma, crumbling relationships, and feelings of a zombie apocalypse.

00:59:10Jul 27, 2026

Maybe It IS Time to Panic Over AI Chatbots and Mental Health with Maggie Harrison Dupré

Plus a look at the mental health implications of GLP-1 medications.

00:55:05Jul 20, 2026

Jo Dee Messina on Hard Times, Jesus, and Her First Album in 12 Years

The country legend has been through a lot and keeps bringing things back to Jesus.

00:51:21Jul 13, 2026

Best of Depresh Mode: Hanif Abdurraqib on Cultivating a Support System, Depression, Anxiety, and Basketball

The acclaimed author talks about living with mental illness and making a beautiful life.

00:50:35Jul 6, 2026

We Should Praise Addiction, Not Condemn It, Says Anthropologist Elizabeth Roberts

It comes down to valuing connection over isolation, community over vice

00:52:06Jun 29, 2026

Cartoonist Gemma Correll Saw a Therapist with a Clown-Festooned Office. Once.

The popular cartoonist has a new graphic memoir about her life on and beyond the edge

00:46:10Jun 22, 2026

RFK Jr. Wants To Take Your SSRIs Away. So What Are Democrats Doing About It?

A talk with Rep. Andrea Salinas (D-OR) about the future of medication availability.

00:50:15Jun 15, 2026

Robyn Hitchcock is Fundamentally Delusional, Welcomes Birds

The veteran musician has a new memoir and album about to drop and gives us a preview.

01:04:46Jun 8, 2026

Blake Mycoskie Helped the World, Got Rich, Retired to a Life of Ease, Then Fell Apart

The TOMS Shoes founder shares his story of highs, lows, and a new podcast.

00:58:16Jun 1, 2026

An Episode About the Grind, Singer Zayna Youssef of Sweet Pill, and YOU

Her band was about to set out on a huge tour but canceled it because of a health crisis.

00:53:51May 25, 2026

Terrifying Times for Immigrants in America and Cristina Jimínez is Incredibly Hopeful

The immigration advocate, author, and MacArthur recipient talks mental health and positive signs.

00:44:53May 18, 2026

Claude Steele on Churn, the Awkward Social Distress That Divides Us All

The eminent social psychologist explains the effects of a situation you have definitely found yourself in.

00:55:46May 11, 2026