BioBytes 45: Protecting the Genome with Alberto Ciccia: DNA Repair, Immunity, and Future Therapies

Alberto Ciccia, Professor of Genetics and Development at Columbia University, joins us to discuss how cells protect their genomes and how these pathways intersect with cancer and immunity. He explains how his lab uses CRISPR-based genome-editing tools to map the DNA damage response and uncover new therapeutic targets. We also talk about his recent Cell study showing how the DNA damage response factor SMARCAL1 shapes immune signaling and tumor immune evasion. Throughout the conversation, Professor Ciccia reflects on mentorship, scientific creativity, and how advances in DNA repair research could translate into better diagnostics and treatments for patients. Hosted by Sophia Deng.

You can listen to BioBytes 45: Protecting the Genome with Alberto Ciccia: DNA Repair, Immunity, and Future Therapies online on Radio and Podcast. Open the player on this page to stream the available audio.

BioBytes 45: Protecting the Genome with Alberto Ciccia: DNA Repair, Immunity, and Future Therapies is an episode from Columbia University Bio Bytes by Columbia Biotech Society.

This episode is 00:39:42 long.

This episode was published on Feb 2, 2026.

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