432. Journal Club: The TRANSFORM-AF Trial with Dr. Sanjeev Saksena and Dr. Varun Sundaram

Dr. Jeanne De Lavallaz  and  Dr. Ramy Doss  discuss the results of the TRANSFORM-AF Trial with expert faculty  Dr. Sanjeev Saksena  and  Dr. Varun Sundaram .   The TRANSFORM-AF trial enrolled 2,510 patients with atrial fibrillation (AF), type 2 diabetes, and obesity across 170 Veterans Affairs hospitals to evaluate the impact of diabetes-dose GLP-1 receptor agonists on AF-related outcomes. Participants were assigned to receive either a GLP-1 receptor agonist, a DPP-IV inhibitor, or a sulfonylurea. The primary composite outcome included AF-related hospitalizations, cardioversions, ablation procedures, and all-cause mortality. Over a median follow-up of 3.2 years, GLP-1 use was associated with a 13% reduction in major AF-related events compared to other therapies. The study population was predominantly male, with a high prevalence of severe obesity (BMI >40 kg/m²) in whom the benefit appeared most pronounced. Notably, the observed benefit occurred despite only modest additional weight loss, suggesting potential non-weight-mediated effects of GLP-1 therapy  This episode was planned in collaboration with Heart Rhythm TV with mentorship from Dr. Daniel Alyesh and Dr. Mehak Dhande.   Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Journal Club Page CardioNerds Episode Page CardioNerds Academy Cardionerds Healy Honor Roll CardioNerds Journal Club

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432. Journal Club: The TRANSFORM-AF Trial with Dr. Sanjeev Saksena and Dr. Varun Sundaram is an episode from Cardionerds: A Cardiology Podcast by CardioNerds.

This episode is 43:05 long.

This episode was published on Oct 29, 2025.

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