The Puzzle of Progression

The Puzzle of Progression – Episode 198 Multiple sclerosis (MS) is evolving—and so is the way we understand it. In this episode, host Stephanie Buxhoeveden sits down with physician’s assistant Lisa Fox to unpack one of the most important shifts in MS care: recognizing progression beyond relapses. They explore the concept of PIRA (progression independent of relapse activity), why patients may feel worse even when MRIs look stable, and how new research, biomarkers, and diagnostic tools are changing the conversation. From distinguishing different progressions to navigating the emotional impact of a changing diagnosis, this episode offers clarity, validation, and hope. This podcast episode was created in collaboration with Novartis. Disclaimer: This podcast provides general educational information. Can Do MS does not endorse, promote, or recommend any product or service associated with the content of this program

You can listen to The Puzzle of Progression online on Radio and Podcast. Open the player on this page to stream the available audio.

The Puzzle of Progression is an episode from Can Do MS Podcast by Can Do Multiple Sclerosis.

This episode is 29:32 long.

This episode was published on Mar 18, 2026.

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