Review Series on Myeloproliferative Neoplasms

In this episode, Blood Associate Editor Dr. Jason Gotlib discusses the Review Series " The New Wave of Targeted Therapeutics for MPN’s ", with authors Drs. Stefan Constantinescu, Ann Mullally, and Marina Kremyanskaya. This Review Series covers 3 areas where exciting advances are occurring. Dr. Constantinescu discusses “ Next-generation JAK inhibitors in the treatment of myeloproliferative neoplasms ” which describes how new ways to switch off JAK signaling are delivering a suite of new small-molecule drugs with potential. Dr. Mullally discusses “ Novel strategies targeting mutant calreticulin in essential thrombocythemia and myelofibrosis ” which reviews the biology of calreticulin mutations in myelofibrosis and ET and how multiple different modalities can be brought to bear against this mutant surface protein, including monoclonal antibodies, bispecific T-cell engagers, and cellular and vaccine therapies. Dr. Kremyanskaya discusses “ Modulators of the hepcidin pathway in polycythemia vera and myelofibrosis ” which outlines the major recent progress being made in controlling excessive erythropoiesis through pharmacological modulation of iron metabolism.

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Review Series on Myeloproliferative Neoplasms is an episode from Blood Podcast by American Society of Hematology.

This episode is 26:09 long.

This episode was published on Apr 2, 2026.

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