Clinical Challenges in Hepatobiliary Surgery: Pancreatic Cysts

Identification of pancreatic cystic lesions has become increasingly common due to improved resolution and increased utilization of cross-sectional imaging. However, there are many types of pancreatic cysts, each with varying degrees of malignant potential. In this episode from the HPB team at Behind the Knife, listen in as we discuss the clinical presentation, diagnostic work-up, and management strategies for various pancreatic cysts: Pseudocysts, Serous Cystadenomas, Mucinous Cystic Neoplasms, and IPMNs, amongst others. Hosts Anish J. Jain MD (@anishjayjain) is a current PGY4 General Surgery resident at Stanford University and a former T32 Research Fellow at the University of Texas MD Anderson Cancer Center. Jon M. Harrison MD is a Hepatobiliary & Pancreatic (HPB) surgeon at the Massachusetts General Hospital in Boston, MA and a former HPB Surgery fellow at Stanford University. Learning Objectives · Develop an understanding of the clinical presentation, diagnostic work-up, and treatment of benign pancreatic cysts · Develop an understanding of the clinical presentation, diagnostic work-up, and treatment of pre-malignant pancreatic cysts · Develop an understanding of when surveillance is appropriate for management of pancreatic cysts, and the criteria involved in making that determination · Develop an understanding of the prognostic utility of PancSeq for IPMNs References: Paniccia A, Polanco PM, Boone BA, et al. Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts. Gastroenterology . 2023 Jan;164(1):117-133.e7. PubMed Link: Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, et al. International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas. Pancreatology . 2024 Mar;24(2):255-270. PubMed Link: Zelga P, Hernandez-Barco YG, Qadan M, et al. Number of Worrisome Features and Risk of Malignancy in Intraductal Papillary Mucinous Neoplasm. J Am Coll Surg . 2022 Jun 1;234(6):1021-1030. PubMed Link: Ciprani D, Weniger M, Qadan M, et al. Risk of malignancy in small pancreatic cysts decreases over time. Pancreatology . 2020 Sep;20(6):1213-1217. PubMed Link: ***Fellowship Application Link: Sponsor Disclaimer: Visit goremedical.com/btkpod to learn more about GORE® SYNECOR Biomaterial, including supporting references and disclaimers for the presented content. Refer to Instructions for Use at eifu.goremedical.com for a complete description of all applicable indications, warnings, precautions and contraindications for the markets where this product is available. Rx only Please visit to access other high-yield surgical education podcasts, videos and more. If you liked this episode, check out our recent episodes here: Behind the Knife Premium: General Surgery Oral Board Review Course: Trauma Surgery Video Atlas: Dominate Surgery: A High-Yield Guide to Your Surgery Clerkship: Dominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: Vascular Surgery Oral Board Review Course: Colorectal Surgery Oral Board Review Course: Surgical Oncology Oral Board Review Course: Cardiothoracic Oral Board Review Course: Download our App: Apple App Store: Android/Google Play:

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Clinical Challenges in Hepatobiliary Surgery: Pancreatic Cysts is an episode from Behind The Knife: The Surgery Podcast.

This episode is 38:26 long.

This episode was published on Mar 23, 2026.

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