57 - The Second Wave

In August of 1918, a horrific second wave of the Spanish Flu crashed across the world. In this episode, the third of a four-part series exploring hydroxychloroquine and COVID-19, I'll explore this single moment in time, through the mysterious origins of the Spanish Flu and historiographical controversies, scientific missions to mass burial sites in remote Alaskan villages, the ill-fated journey of the HMS Mantua, debates about how to count victims of a pandemic, and the mystery behind Pfeiffer's bacillus. Plus a new about that annoying yellow on blue powerpoint template so common in the medical field! Sources: Viboud, C. et al. Age- and Sex-Specific Mortality Associated With the 1918–1919 Influenza Pandemic in Kentucky. J Infect Dis 207 , 721–729 (2013). Oxford, J. S. & Gill, D. A possible European origin of the Spanish influenza and the first attempts to reduce mortality to combat superinfecting bacteria: an opinion from a virologist and a military historian. Hum Vacc Immunother 15 , 2009–2012 (2019). Epps, H. L. V. Influenza: exposing the true killer. J Exp Medicine 203 , 803–803 (2006). Patterson, S. W. & Williams, F. E. PFEIFFER'S BACILLUS AND INFLUENZA. Lancet 200 , 806–807 (1922). Taubenberger, J. K. & Morens, D. M. The 1918 Influenza Pandemic and Its Legacy. Csh Perspect Med a038695 (2019) doi:10.1101/cshperspect.a038695. Trilla, A., Trilla, G. & Daer, C. The 1918 "Spanish Flu" in Spain. Clin Infect Dis 47 , 668–673 (2008). Taubenberger, J. K. The origin and virulence of the 1918 "Spanish" influenza virus. P Am Philos Soc 150 , 86–112 (2006). Heinz, E. The return of Pfeiffer's bacillus: Rising incidence of ampicillin resistance in Haemophilus influenzae. Microb Genom 4 , (2018). Barry, J. M. The site of origin of the 1918 influenza pandemic and its public health implications. J Transl Med 2 , 3 (2004). Johnson, N. P. A. S. & Mueller, J. Updating the Accounts: Global Mortality of the 1918-1920 "Spanish" Influenza Pandemic. B Hist Med 76 , 105–115 (2002). Tomkins SM, Colonial Administration in British Africa during the Influenza Epidemic of 1918-19. Canadian Journal of African Studies / Revue Canadienne des Études Africaines. Vol. 28, No. 1 (1994), pp. 60-83 (24 pages) Qiang Liu et al, The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell Mol Immunol. 2016 Jan; 13(1): 3–10. Spreeuwenberg et al. Reassessing the Global Mortality Burden of the 1918 Influenza Pandemic.Am J Epidemiol . 2018 Dec 1;187(12):2561-2567. doi: 10.1093/aje/kwy191. R. F. J. Pfeiffer: Vorläufige Mittheilungen über den Erreger der Influenza. Deutsche medicinische Wochenschrift, Berlin, 1892, 18: 28. Die Aetiologie der Influenza. Zeitschrift für Hygiene und Infektionskrankheiten, 1893, 13: 357-386.

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57 - The Second Wave is an episode from Bedside Rounds by Adam Rodman.

This episode is 45:18 long.

This episode was published on Aug 31, 2020.

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